The first punch in this video did most of the damage. Note that Tom punches around the bar, using his arms only. A normal person cannot punch effectively like this. The important technical aspects of Tom's success—and lack of a broken right hand—are the fact that he jabbed first, and then threw the right, and that he threw the first right open handed as the face was not yet targeted with that hand. The open hand is more important than the fist in bare knuckle fighting. Scoring with it still jars the neck and can KO, and also develops clinch control and targeting with the other hand.
If You're Not Vietnam Tom
If you lack Tom's freakish genetic gifts and are in a poor leverage position throw a jab just like Tom did, but with your fingertips, into the eyes. Bend the fingers inward slightly to keep from spraining or breaking them.
If you don't want to get this skanky, or if you need to KO the fool in a hurry, hit him with the bus.
Yes, hit him with the bus.
This is very simple.
If he is behind you hit him when the bus accelerates.
If he is in front of you, hit him when the bus brakes.
If he is on the sidewalk side of the bus hit him when the bus is banking in to a stop.
If he is on the street side of the bus hit him when the bus banks out into traffic.
You may grab a bar to stabilize your self and even let your body swing through the target.